Flytrapguy

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    • Myriad Options on Alzheimers Disease [view article]
      Bravo for the excellent discussion.

      There is a very large retrospective study on 100,000+ veterans that was just published that shows that ibuprofen, an Ab42 lowering drug, does indeed appear to be protective in Alzheimer's disease. See: Neurology. 2008 May 6;70(19):1672-7 "Protective effects of NSAIDs on the development of Alzheimer disease. Vlad SC, Miller DR, Kowall NW, Felson DT.

      From the abstract: "...RESULTS: We identified 49,349 cases and 196,850 controls. Compared with no NSAID use, the adjusted odds ratios for AD among NSAID users decreased from 0.98 for <or=1 year of use (95% CI 0.95-1.00) to 0.76 for >5 years of use (0.68-0.85). For users of ibuprofen, it decreased from 1.03 (1.00-1.06) to 0.56 (0.42-0.75)."

      This is not a clinical trial. However, it is the largest study to date that has examined the relationship between NSAIDs use and Alzheimer's disease.       May 15 02:40 PM
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