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Myriad Options on Alzheimers Disease [view article]
Some of the scientific info in this post is wrong. The naproxen and celebrex trial were designed to test the affect of COX inhibition on alzheimer's disease, since naproxen and celebrex do NOT inhibit gamma secretase.

The Archives of Neurology article cited in this post say it best:
"It may be that the ADAPT findings relate specifically to celecoxib or naproxen, perhaps because these drugs are not among those NSAIDs that have been shown in vitro and in vivo in mouse models to lower production of the 42-residue form of amyloid β (Aβ42)21; that is, the epidemiological findings could be due to the effects of other NSAIDs, such as the commonly used ibuprofen, that do lower Aβ42. More speculatively, the ADAPT findings may represent early detrimental effects following initiation of treatment in people who have subclinical neuropathology. That is, NSAIDs might exert protective effects only if given several years before the time when symptoms would otherwise develop. Such a difference in effect has been suggested by results of both the Rotterdam22 and Cache County23 observational studies, which showed apparent protective effects with more distant, but not recent, use of NSAIDs." May 13 09:29 AM

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